Principal Data Scientist, In Silico Antibody Design

At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in science, we believe that being proudly unique, determined to be our best, and authentic is essential to fulfilling our purpose.

The role

Within the Cell and Molecular Biology (CMS) department at Genmab we have an open position for a Principal Data Scientist.  You will be embedded within a team of Molecular Biologists and complement this team with state-of-the-art knowledge about in silico sequence-based predictions.

Within this team we focus on technology innovation specifically focused on the generation of new antibody discovery pipelines, generation of antibody libraries and development of sequence-based antibody characterization methods. The CMS department is embedded in the Antibody Discovery Technologies cluster highly collaborating with departments focusing on innovation with respect to high throughput screening, protein production, purification and characterization and automation.

You are passionate about high volume sequence-based challenges and have a proven track record with the generation of sequence-based machine learning models. You are an Innovative and curious thinker, enthusiastic and passionate to drive new innovations. Furthermore, you have a practical and focused mindset, and you are well organized.

Responsibilities

• You will complement the team with your experience with the development of antibody-based prediction pipelines, participating in building prediction models at the intersection of molecular biology and data science.

• You will build and implement prediction models focused on the generation of antibody libraries and development of sequence-based antibody characterization methods (e.g. humanization, immunogenicity, affinity and epitope/paratope mapping).

• Your knowledge will be applied to specific problems in the protein sequence space like library design optimization, establishing protein characteristics based on enrichment studies, generation of sequence-based prediction models, antibody optimization and de novo antibody design.

• Genmab is a highly collaborative environment. You will work in close collaboration with other data scientists within the organization as well as participate with scientist responsible for new antibody formats, new antibody products and discovery technologies programs.

• Besides hands-on activities, you are expected to initiate and participate in the formation of strategies and future plans and participation in external communities.

Requirements

• You hold a PhD degree in the field of immunology, computational biology or bioinformatics.

• You have 8 years' experience preferably in the antibody field, ideally in the Biotech industry

• You are a strong communicator and able to bridge biology within silico approaches.

• You have experience with large sequence libraries and translate this towards protein prediction and optimalization.

• You have a proven track record in combining wet lab expertise with computational techniques, e.g. with the development of sequence-based prediction models (AI/ML models).

• You have excellent programming skills and expert knowledge of Python and SQL. Java knowledge and experience with Genedata is considered a big plus.

• You have a forward looking and strong strategic mindset.

• You are enthusiastic, creative, goal orientated, pro-active and out-of-the-box thinking with a strong ability to work independently.

• Team player with excellent interpersonal and communication skills with great command of English, written and spoken, Dutch not required.

• Ability to work 32-40 hours/week and approx. 3 days per week at our office in Utrecht.

About You

• You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
• You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
• You are a generous collaborator who can work in teams with diverse backgrounds
• You are determined to do and be your best and take pride in enabling the best work of others on the team
• You are not afraid to grapple with the unknown and be innovative
• You have experience working in a fast-growing, dynamic company (or a strong desire to)
• You work hard and are not afraid to have a little fun while you do so

Locations

Genmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you’re in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.

About Genmab

Founded in 1999 in Copenhagen, Denmark, Genmab is an innovative biotech company that has become a leader in antibody biology and innovation. Our product pipeline and next-generation antibody technologies are the result of our strong company culture, a deep passion for innovation, and desire to transform cancer treatment and serious diseases.

When you work with us, you’ll be part of a warm, fun, dynamic community, and team up with some of the best, most authentic individuals in locations around the world, who care deeply and share in a relentless drive to innovate and create transformational medicines. People who are candid, impact-driven, and a little unconventional; who seek out and embrace the opportunity to build new and bold futures within a rapidly growing and innovative biotech company; who bring their full selves to work and show up for each other - rolling up their sleeves to get the job done. This translates into a place where you can be authentically you; are empowered to innovate, build solutions, and execute; feel cared for and supported in growth; and are a critical part of changing the lives of patients around the world through transformative cancer treatment.

Our commitment to diversity, equity, and inclusion

We are committed to fostering workplace diversity at all levels of the company and we believe it is essential for our continued success. No applicant shall be discriminated against or treated unfairly because of their race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), national origin, age, disability, or genetic information. Learn more about our commitments on our website .

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website https://www.genmab.com/privacy .

Please note that if you are applying for a position in the Netherlands, Genmab’s policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the fixed-term employment contract.