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Principal Scientist mRNA (m/f/d)

Geleen, Netherlands
Netherlands, Geleen

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world , a nd that’s the kind of work we want to be part of.

For mRNA Business unit , located in Geleen, Netherlands we have exciting opportunities. Become part of a group that enables its customers to meet some of the greatest challenges in patient treatment and join us by applying for the position as a Principal Scientist mRNA in Process Development .

Key responsibilities :

  • Representation: act as a deputy of the team manager when needed and support the process development management.

  • Leadership: provide strong scientific, technical and regulatory leadership at project level. Lead individual scientists and lab technicians on complex projects.

  • Projects: lead multi-disciplinary matrix teams on complex projects in the area of scientific expertise . Lead problem solving and lessons learned activities.

  • Scientific tasks: design of advanced experimental plans and their execution, in process data analysis, write and review high quality reports.

  • Customer interactions: develop strong customer relationships.

  • Training: lead training activities in the area of expertise.

  • Provide solutions to identified risks, issues, problems. Report issues in a timely fashion.

  • Facilitate improvements to departmental business processes and contribute to the implementation of innovative technologies.

  • Demonstrate flexibility to support other activities within the department.

  • Proactive approach to own continuous professional development.

Key requirements :

  • Deep Understanding of IVT critical process parameters , reaction optimization and scale-up .

  • Experience in mRNA manufacturing in batch and controlled ( bioreactor ) modalities .

  • Experience with a wide range of mRNA analytical techniques for large nucleic acid molecules , in particular with analytical assays associated with IVT and purification processes .

  • Implementation of DOE studies & high- throughput screening for IVT and purification processes .

  • Knowledge of technology transfer and GMP manufacturing .

  • General understanding and experience of purification techniques such as chromatography ( including affinity , ion exchange hydrophobic interactions , etc.) and tangential flow filtration (TFF).

  • Demonstrated ability to efficiently work in a fast paced and fluid environment .

  • Knowledge of molecular biology and mRNA constructs design.

  • Experience within the manufacturing of large mRNA molecules including self-amplifying RNAs and circ ular RNAs would be a plus.

  • General understanding of the mRNA-LNP encapsulation process and relevant associated analytical methods .

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference .

Reference: R58617
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