Intern, Discovery Preparation & Humanization (Project: Implementation of automated Nanodisc screening and characterization)

At Genmab, we are dedicated to building extra[not]ordinary® futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines® that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals’ unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees.

Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so.

Does this inspire you and feel like a fit? Then we would love to have you join us!

Interested in more than one internship with us?

We are posting several projects within our Utrecht Genmab site, each with its own research focus, recruitment team, and selection process. Please take time to explore the available projects and apply to a maximum of two that best match your interests and skills.

If you apply to two, include the project titles in order of preference in both motivation letters , with a brief explanation of your interest in each. This helps our teams understand your preferences throughout the separate selection processes!

The Role

How do you generate high-quality tools for antibody characterization? Are you excited about multi-pass membrane proteins and studying their behavior with cutting edge techniques? If this interests you, keep on reading!

Well characterized tumor-associated antigens are crucial tools in the development of antibody therapies, and Genmab’s innovative antibody formats continuously lead the way to new and innovative treatments for patients. Many of the therapeutic targets are proteins that are embedded into the membrane of a cell. Detailed characterization of therapeutic molecules to their respective target protein is crucial to increase understanding and drive successful development of new medicines. For proteins that pass through the membrane multiple times, it can be challenging to perform this type of characterization as it is difficult to recapitulate them in the correct environment.

In this internship within the Discovery Preparation and Humanization and the Protein Science and Technology team, you will work on the implantation of nanodisc technology.  Specifically, the intern will focus on setting up an automated workflow to screen and purify membrane bound proteins in nanodiscs. Subsequentially, these materials will be characterized via various biochemical and biophysical techniques to determine their quality. Ultimately, these protein nanodiscs can be used in the screening of antibody panels, research of protein biology, and structural characterization of the antibody and target complex.

The final project will take shape through discussions with you. The exact research question and experimental approach have not yet been finalized. Together with your supervisor, you will define a project that brings together the team’s research priorities, your scientific interests, and your university’s learning objectives, within the time and resources available.

Does this sound like something that interests you? We look forward to receiving your application and exploring the possibility of you joining our team to contribute to the advancement of antibody therapeutics! Help us get to know you by submitting a CV and motivational letter!

Responsibilities

The exact project scope and responsibilities will be set at the start of the project. These will be along the lines of:

• Optimize cell culturing and lysis protocols.

• Set up automated screening and purification of Nanodiscs.

• Analyze and characterize the behavior of various membrane protein topologies using biochemical and biophysical techniques.

• Apply these materials in use cases within the wider Discovery organization.

• Report and present your progress and findings to multiple stakeholders within the company.
  

Requirements

• Currently enrolled in an HBO or Master’s degree program at a Dutch university in Molecular Biology, Life Sciences, Biomedical Sciences, or a related field.

• This internship must be a formal, mandatory component of your degree program required for graduation; we cannot consider candidates who have already graduated or who are seeking an extracurricular internship.

• Available for a minimum of 7 months.

• Knowledge and understanding of protein purification and characterization techniques, such as affinity purification, SDS-PAGE, Size Exclusion Chromatography is preferred.

• Knowledge and understanding of protein biogenesis is preferred.
  

General Information

• Internship duration: a minimum of 7 months, preferably 9 months due to the complexity of the project.

• Start date: 1 Feb/March 2027 (fixed start dates aligned with our internship cohorts, so you can join fellow students for onboarding and make the most of the shared learning activities throughout your internship).

• Location: Utrecht, Netherlands.

• Working arrangement: This is a full-time, on-site internship position.

Intended Recruitment Timeline

• Application deadline : 1 December 2027.
• Shortlisting: 2-7 of December 2027
• Initial online screenings: 8-9-10 of December 2027.
• Onsite interviews: Week of 14th of December 2027.
  

The proposed gross annual base salary range for this position, in the primary location, based on a full time schedule is:

EUR750,00---750,00

The final salary offer will depend on several factors, including your skills, qualifications, and experience.

In addition to base salary, this position is eligible for additional forms of compensation, such as discretionary bonuses and long-term incentives.

When you join Genmab, you become a part of a culture that supports your physical, financial, social, and emotional well-being. Our benefits include, but are not limited to:

• Pension
• Health insurance and wellness benefits
• Paid time off
• Employee support programs

Further details on eligibility for compensation and benefits based on the role will be provided during the recruitment process.

About Genmab

Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard-working, innovative and collaborative team has invented next-generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO®) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X .

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website Job Applicant Privacy Notice (genmab.com) .

Please note that if you are applying for a position in the Netherlands, Genmab’s policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the contract.