Senior Scientist, Organic & Medicinal Chemistry

The Role

We are seeking a highly motivated and skilled Senior Scientist Organic & Medicinal Chem i stry to join our dynamic team at the Discovery department of Genmab in Ut r echt . As a key member of our new chemical lab, you will play a n important role in driving the development of A ntibody D rug C onjugate s in a fast-paced and innovative biotech environment. Your expertise in medicinal and organic chemistry will be instrumental in designing, synthesizing, and optimizing novel compounds to advance our research and development pipeline.

If you are an innovative and driven scientist looking to make a significant impact in a cutting-edge biotech, we invite you to apply for this exciting opportunity.

Responsibilities

• Compound Design and Synthesis: Develop and synthesize novel organic compounds and medicinal agents to support drug discovery and development projects. Apply medicinal chemistry principles to design compounds with optimal pharmacological properties and ensure conjugation to Genmab’s Antibody formats . Development and implementation of innovative synthetic methodologies and strategies to enhance efficiency, scalability, and overall project success.

• Optimization and Analysis: Conduct structure-activity relationship (SAR) studies to optimize lead compounds. Utilize advanced analytical techniques, including HP LC , LC- MS, NMR , and other methods to characterize and purify compounds.

• Collaboration: Work closely with cross-functional teams, including biologists, pharmacologists, and other chemists, to integrate chemistry efforts into broader research and development activities. Contribute to the planning and execution of experiments that drive project milestones.

• Innovation: Stay abreast of the latest scientific advancements and technologies in medicinal and organic chemistry. Apply innovative approaches to solve complex problems and contribute to the development of new research strategies.

• Documentation and Reporting: Maintain accurate and detailed records of experimental procedures, results, and analyses. Prepare and present scientific reports, manuscripts, and presentations to internal and external stakeholders.

• Quality and Compliance: Ensure that all work is conducted in compliance with company policies, industry regulations, and best practices. Participate in safety and compliance training as required .

Requirements

• Educational Background: Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field, with a strong foundation in both theoretical and practical aspects of medicinal and organic chemistry.

• Experience: Minimum of 3-5 years of experience in medicinal and/or organic chemistry, preferably in a startup or innovative biotech environment. Proven track record of successful compound design, synthesis, and optimization.

• Technical Skills: Proficiency in organic synthesis techniques and analytical methods, including NMR, MS, HPLC, and other relevant technologies. Experience with parallel synthesis, high-throughput screening and SAR analysis is a plus.

• Analytical Thinking: Strong problem-solving skills with the ability to analyze complex data and derive actionable insights. Demonstrated ability to design and execute experiments independently.

• Collaboration: Excellent interpersonal and communication skills with a demonstrated ability to work effectively in a team-oriented environment. Experience in collaborating with cross-functional teams is highly desirable.

• Adaptability: Ability to thrive in a fast-paced startup environment with a flexible and proactive approach to work. Willingness to take on diverse tasks and responsibilities as needed.

• Passion for Innovation: Enthusiasm for working in an innovative biotech setting and a commitment to advancing scientific research and development.