Principal Scientist MSAT LM DS Lab

Description

Johnson & Johnson is currently seeking a Senior Scientist to join our dynamic Manufacturing Science and Technology (MSAT) Lab in Leiden, the Netherlands.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

The MSAT Lab operates within the Large Molecule Drug Substance (LM DS) platform, which is a segment of the global MSAT organization.

As we work to enhance MSAT capabilities to fully own our current and future commercial products, we are establishing a dedicated MSAT LM DS Lab specializing in Large Molecules (mAbs, complex glycoproteins, bi- & tri-specifics). This lab will house small-scale equipment including 2-10 L bioreactors (fed-batch and continuous perfusion), downstream processing and process analytical lab equipment.

The MSAT Lab will support Life Cycle Management of commercial products and Secondary Technology Transfers. Our lab will conduct satellite runs in Leiden and for EU & Row address complex investigations, process improvements, and serve as a non-routine sample hub.

You will be a highly valued member of our team, playing a critical role in leading complex investigations and driving robust and reliable downstream processes for our global commercial portfolio. You will work independently, leveraging your extensive expertise to execute experiments, analyze data, and contribute to the advancement of key projects. You will act as a mentor and guide to junior scientists, fostering a culture of scientific excellence and innovation within the team.

Are you a highly accomplished and results-driven scientist with a deep understanding of downstream processes in large molecule manufacturing? Do you thrive in a challenging and collaborative environment where you can make a significant impact on the development of innovative therapies? If so, we invite you to join our team!

Key Responsibilities:

• Downstream Process Investigations & Optimization:- Lead the design, execution, and analysis of complex investigations related to downstream processes, aiming to optimize step yields, increase robustness and reliability of our LM products, and enhance our understanding of key process parameters.
• Contribute to the development and implementation of robust and scalable downstream processes (reduced scale models), ensuring alignment with global manufacturing strategies.
• Troubleshoot complex process challenges and identify innovative solutions for improvement.

• Data Analysis & Interpretation:- Analyze experimental data independently, drawing insightful conclusions and preparing clear and concise reports.
• Effectively communicate results to colleagues and stakeholders, both locally and globally, presenting complex findings with confidence.

• Technical Expertise & Innovation:- Stay at the forefront of the latest advances and technologies in downstream process development, continuously seeking new ways to enhance efficiency, robustness, and reliability.
• Proactively contribute to the development and implementation of technical solutions to address manufacturing challenges, proposing innovative approaches and solutions.

• Leadership & Mentorship:- Provide guidance and mentorship to junior scientists, sharing your expertise and fostering their professional development.
• Encourage a culture of scientific excellence and collaboration within the team.

• Global Collaboration:- Collaborate effectively with colleagues across different locations, engaging in global initiatives and sharing knowledge to drive consistent process development and optimization.
• Effectively communicate with stakeholders at all levels, providing clear and concise updates on project progress and ensuring alignment with global strategic objectives.

Qualifications

• Educational Background:
• MSc / PhD in a relevant field, such as Biochemistry, Biotechnology, Chemical Engineering, or a related field.

• Experience:
• 8+ years of relevant experience with a Master’s degree or equivalent, demonstrating a proven track record of success in leading complex downstream process investigations and driving technical solutions.

• Hands-on experience with purification techniques, chromatography, UF/DF, and process optimization, with a strong understanding of various downstream technologies and their applications.

• Technical Skills:
• In-depth understanding of downstream processes for large molecule drug substances and a thorough knowledge of various downstream technologies and their applications.

• Proficiency in data analysis and interpretation, using statistical methods and advanced data analysis tools.

• Familiarity with regulatory guidelines and good manufacturing practices (GMP), ensuring compliance with relevant regulations.

• Problem-Solving & Analytical Skills:
• Demonstrated ability to solve complex scientific and technical challenges independently and within a team setting, using a critical and analytical approach to problem-solving.

• Strong analytical skills, with the ability to critically evaluate data and draw sound conclusions, effectively communicating insights and recommendations.

• Communication & Leadership:
• Excellent communication and interpersonal skills, effectively conveying complex scientific information to diverse audiences, including both technical and non-technical stakeholders at all levels in the organization.

• Proven ability to lead and inspire others, fostering a positive and collaborative work environment and promoting a culture of scientific excellence and innovation.

Janssen Biologics in Leiden, the Netherlands, is a leading site for commercial & clinical manufacturing in the dynamic business of Biotherapeutics and Advanced Therapy. We combine our proven strengths with innovation to meet the needs of today and tomorrow. At Janssen Biologics, enthusiastic people are working together in a dynamic culture where innovation and driven mentality are common good. We are proud of our Credo values and our diverse environment and commit to the highest safety, quality, and sustainability standards. The site and portfolio are growing rapidly which transforms the way we support our patients. Together, we strive for a future in which disease is a thing of the past. Passionate about our mission? Join our team. Make your mark!

For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges.

We know that the success of our business – and our ability to deliver meaningful solutions – depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential.

At Johnson & Johnson, we all belong.