Intern, Discovery Data Science (Project: Spatial Malignant Cell Annotation)

At Genmab, we are dedicated to building extra[not]ordinary® futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines® that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals’ unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees.

Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so.

Does this inspire you and feel like a fit? Then we would love to have you join us!

Why Genmab
Our internship program provides interns with hands-on experience and meaningful projects that directly contribute to our company’s goals. Additionally, we believe that our program offers not just a chance to learn but also the opportunity to grow, network, and play a critical role in our efforts to make a difference for patients, every single day.

Project

Targeted cancer therapies have shown therapeutic advantages due to tumor-specific drug activity. Single-cell and spatial transcriptomics has been widely used in cancer studies to define different cellular identities. However, accurate identification of tumor vs other normal cells is essential to define novel tumor-specific targets. At Genmab, we recently developed MACE ( https://www.biorxiv.org/content/10.1101/2025.01.13.632750v1 ), a consensus cancer annotation framework, which combines the two major categories of cancer cell annotation methods: CNV-based and Reference-based, producing overall higher precision tumor annotation, leading to confident tumor-specific potential therapeutic targets. Furthermore, incorporating the spatial information from spatial transcriptomics data will add a crucial layer of information that helps to further refine the identification of tumor-specific targets, making targeted therapies even more effective.

The Role
As a Data Science Intern, you will play an important role within our Discovery Data Science team at Genmab, focusing on the development and evaluation of machine learning methods. You will be trained in performing advanced single-cell data analysis, interpreting the results, effectively communicating findings to a diverse audience, and project planning. Additionally, you will gain exposure to the strategic design of innovative antibody therapeutics that aim to address a high unmet need in oncology. An internship at Genmab will provide you with the opportunity to experience the dynamic environment of a world-class biotech company!

Goals

The main aim of this “SpaceMACE” project is to extend MACE to annotate tumor cells using spatial transcriptomics data, making use of the spatial neighborhood information to enrich the annotation of tumor vs normal cells of the tumor microenviroment.


Responsibilities

• Research, develop, and evaluate machine learning methods for cell annotation.
• Conduct a literature review to explore the current spatial transcriptomics efforts in the oncology field.
• Perform advanced data analysis of single-cell sequencing tumor datasets.
• Translate findings into insights to inform antibody product discovery.
• Document research findings, algorithm developments, and test results comprehensively through reports and presentations.

Requirements

• Enrolled in a Master’s program in Computer Science, Biomedical Sciences, Bioinformatics, or a related field at an University in the Netherlands. Please note that you need to be actively enrolled throughout this internship.
• You have experience with R and/or Python programming.
• You have a strong interest in machine learning, data analysis, and algorithm development.
• You have a foundational knowledge of cancer biology and/or immunology.
• You have experience in, or a strong interest in learning, single-cell data analysis and antibody drug discovery.
• You enjoy working collaboratively in a multidisciplinary team.

General Intern Information

• Internship duration: 6-12 months.
• Start date: preferably September 1st, or later.
• Location: Utrecht, Netherlands.
• Hybrid schedule: at least 3 days in the office, 2 days remote per week.

What’s Next?
Help us learn about you by submitting a complete and thoughtful application, including your resume and motivational letter . Your application and resume are our first introduction to you, so please complete all relevant application questions to provide as much information as possible.

We will review each submission as quickly as possible to determine whether you meet the qualifications for the role. Due to the volume of applications, we cannot respond to inquiries regarding application status. If you advance to the next step, you will receive an invitation for further discussion. The final step includes interviews with hiring team members, after which we will communicate final decisions to all interviewed candidates.

We look forward to receiving your application and exploring the possibility of you joining our team to contribute to the advancement of antibody therapeutics!

About You

• You are genuinely passionate about our purpose

• You bring precision and excellence to all that you do

• You believe in our rooted-in-science approach to problem-solving

• You are a generous collaborator who can work in teams with a broad spectrum of backgrounds

• You take pride in enabling the best work of others on the team

• You can grapple with the unknown and be innovative

• You have experience working in a fast-growing, dynamic company (or a strong desire to)

• You work hard and are not afraid to have a little fun while you do so!

Locations

Genmab maximizes the efficiency of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are crafted as open, community-based spaces that work to connect employees while being immersed in our powerful laboratories. Whether you’re in one of our office spaces or working remotely, we thrive on connecting with each other to innovate.

About Genmab

Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard-working, innovative and collaborative team has invented next-generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO®) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X .

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website Job Applicant Privacy Notice (genmab.com) .

Please note that if you are applying for a position in the Netherlands, Genmab’s policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the contract.