Intern - (Physical) Chemistry - PATS

Job Description

We are looking for a motivated fourth-year HBO bachelor or WO master student (Physical) Chemistry! Do you want to know what it's like to be part of one of the largest multinational companies in the pharmaceutical industry? We offer an internship opportunity within our PATS department where you will have the freedom and space for your own initiative.

Intern – (Physical) Chemistry – PATS Material Science and Characterization

Welcome to our team
The PATS department (Material Science and Characterization group) is an essential hub in our organization. This department is focused on physicochemical analytics. For this project we are collaborating with the process technology department. The project will be a close collaboration and an internship will be a great chance to gain experience within the pharmaceutical industry

Your internship assignment
To assure the continuity of the supply of all raw materials for a protein crystalline drug product the seed crystals must be replaced by an alternative source. Our drug product manufacturing uses seed crystals to control the crystallization of the API. As an intern:

• You work on the optimization of an alternative manufacturing method for the crystalline seeds:

• Increase the understanding of the fundamental crystallization process. Identify the critical process parameters and corresponding set-points to control the particle size and crystallinity of the protein seed crystals.

• Prepare the final protein drug product at lab scale to compare the effectiveness of your alternative protein crystal seeds in controlling the crystallization of the final protein crystalline drug product.

The commercial manufacturing process of the drug product is downscaled to 0.7 L using a Mettler Toledo Optimax lab reactor. This reactor set-up is also evaluated as a representative model to simulate the commercial aseptic preparation of the protein drug product.

Your responsibilities

• Perform the lab scale experiments to screen for the critical process parameters and optimize the set-points of the critical process parameters for manufacturing of the alternative protein seed crystals, DOE can be part of the project.

• Prepare the final protein drug product at lab scale to evaluate the effectiveness of your alternative seeds against no seeding and seeding with the current source of protein seed crystals.

• Implementation and use of an inline microscope to follow the crystallization process.

• Analyze the resulting material with a.o. laser diffraction, optical microscopy, determination of crystallinity and other techniques.

• Evaluate the results and suggest adjustments.

• Providing a fresh perspective within the department: your opinion matters.

The described tasks form the basic package and will often be performed independently after a proper training and learning period. These tasks may be supplemented with other projects and/or tasks on your own initiative or at the request of the organization.

What is required

• A 4th year bachelor (HBO) or master student in (physical) chemistry

• You are familiar with crystallization and/or chemical process development

• You are enthusiastic about crystallization of APIs and/or proteins in the pharmaceutical industry

• You are searching for an internship where you have the freedom to take initiative

• You are fluent in English

• You are available for a period of 6 – 9 months for 5 days a week.

What we offer

Interning at our company means working together with your team towards health in an international work environment. As an intern, you will have the opportunity to work closely with experts and learn from them. In addition, we offer:

• The chance to gain experience in the pharmaceutical industry

• An opportunity to showcase yourself for potential opportunities after your internship period

• A challenging and dynamic work environment with plenty of room for personal development and initiative

• Good guidance from an experienced specialist

• A gross monthly internship allowance of €500,- based on a 40-hour workweek

Animal Health Division

Our Animal Health Division is a trusted global leader in animal healthcare. We are committed to preserving and improving the health, well-being, and performance of animals and the people who care for them. As a global team of professionals, we work together to make a positive difference in animal care and the world's food chain. We also have a deep sense of responsibility towards our customers, consumers, animals, society, and our planet.

By being dedicated to The Science of Healthier Animals®, we provide veterinarians, farmers, pet owners, and governments with one of the broadest ranges of animal health products, vaccines, and solutions and services for health management. Additionally, we deliver a comprehensive range of digitally connected identification, traceability, and monitoring products. We invest in dynamic and extensive R&D capabilities and a modern, global supply chain. We are present in more than 50 countries, and our products are available in approximately 150 markets.

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Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Intern/Co-op (Fixed Term)

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Not Applicable

Shift:

Valid Driving License:

Hazardous Material(s):

Job Posting End Date:

08/12/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 08/12/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R297363