Internship Medicinal & Protein Chemistry

Byondis is an independent Dutch biopharmaceutical company, based in Nijmegen, that focuses on developing innovative medicines against cancer and autoimmune diseases. We are driven by one goal: to develop new treatments to improve the standard of care for patients. We are always seeking to recruit the very best talent. People who think outside the box, highly skilled individuals that want to continually expand their knowledge. Byondis provides a dynamic workplace where all ideas are welcome, teamwork is key and the values of trust, quality, entrepreneurship, integrity and authenticity are of paramount importance.

The Medicinal & Protein Chemistry department is looking for a Bachelor or Master level (HBO or University) student for an internship or graduation internship for a minimum period of 5 months starting March 2025. Preferably you already completed a relevant internship at another company or at a university with relevance in organic chemistry or molecular lifesciences.

Brief general description for MPC1/2: Design, synthesis and characterization of novel payload and linker-payload molecules as intermediates for the synthesis of antibody-drug conjugates. The project comprises route design, multistep synthesis, purification by multiple techniques and basic characterization of intermediates and end products by for example HPLC, LC-MS and NMR. End products (free payloads and conjugates thereof) will be evaluated by our in vitro pharmacology group and results will be reported back to establish a structure-activity relationship.

Brief general description for MPC3: Design, synthesis, purification and characterization of novel antibody-drug conjugates and similar conjugates. The project comprises conjugation of small molecules to antibodies or other proteins, purification by multiple techniques, such as column chromatography and filtration, and basic characterization of the conjugates by for example different HPLC-based techniques. Conjugates will be evaluated by our in vitro pharmacology group and results will be reported back to support further optimization.

We offer you a dynamic working environment at our state-of-the-art campus in Nijmegen. Our values as integrity, authenticity, entrepreneurship, quality and trust are very highly regarded.

And ofcourse we pay you an internship allowance.

If you want further information before you apply, please send an e-mail to Recruitment@byondis.com